Talanoa Hufanga

49ers declared S Talanoa Hufanga, QB Joshua Dobbs, CB Darrell Luter Jr., WR Ronnie Bell and OL Ben Bartch inactive for Week 4 against the Patriots.

Hufanga is now out with an ankle injury, one week after making his 2024 debut following his 2023 ACL reconstruction. The 49ers will fortunately have Williams (illness, toe) protecting Brock Purdy’s blindside though. Deebo Samuel Sr. is active as well. He remains a high-ceiling WR1, though the 49ers could opt to rest him late in the game if they establish a comfortable lead, as expected.