Deebo Samuel Sr.

49ers HC Kyle Shanahan said WR Deebo Samuel (calf) will miss “a few weeks.”

Samuel picked up a calf strain at some point in the 49ers’ Week 2 loss to the Vikings and is expected to miss time. It’s a massive blow to a team already without Christian McCaffrey due to Samuel’s increased rushing workload and schemed usage through the air in the absence of the All-Pro running back. George Kittle, Brandon Aiyuk, and Jordan Mason will be asked to step up in their collective absence, while Jauan Jennings is likely to see a slight uptick in offensive snaps.