Isaac Guerendo

ESPN’s Adam Schefter reports Isaac Guerendo (hamstring) is unlikely to play in Week 16 against the Dolphins.

The 49ers will feature their fourth running back of the season on Sunday against the Dolphins if Guerendo can’t suit up. Guerendo was a DNP in Wednesday’s practice, but it sounds like the team is already preparing to be without the rookie. It’s hard to know what direction the 49ers could go in here, but Patrick Taylor figures to be first in line for touches as the most-tenured member of the Niners. Ke’Shawn Vaughn and Israel Abanikanda only recently joined the team after it was revealed Christian McCaffrey and Jordan Mason would be placed on injured reserve, but both backs could also work into the mix even if Taylor operates as the lead back.